Interferon-gamma is necessary for the expression of hypersensitivity pneumonitis.

  title={Interferon-gamma is necessary for the expression of hypersensitivity pneumonitis.},
  author={G Steinar Gudmundsson and Gary W. Hunninghake},
  journal={The Journal of clinical investigation},
  volume={99 10},
Farmers lung disease is a common form of hypersensitivity pneumonitis (HP) and is characterized by inflammation and granuloma formation in the lung. Interferon-gamma is important for the expression of granulomatous diseases caused by infectious agents; however, the role this mediator in regulating expression of the granulomatous response to inhaled antigen is not known. To evaluate this, we compared the response to inhaled antigen of mice that do not express the gene coding for interferon-gamma… CONTINUE READING
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