Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.

@article{Igarashi1994InterferongammaIT,
  title={Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.},
  author={Kazuhiko Igarashi and Gianni Garotta and L. Ozmen and Andrew Ziemiecki and Andrew F. Wilks and Ailsa G. Harpur and Andrew C Larner and David S. Finbloom},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 20},
  pages={14333-6}
}
Interferon-gamma (IFN-gamma) induces the expression of a set of early response genes by tyrosine phosphorylation of latent transcription factors such as p91. Although the tyrosine kinases, Jak1 and Jak2, have recently been shown to be critical for signal transduction by IFN-gamma, evidence is lacking for both tyrosine phosphorylation of the IFN-gamma receptor (IFN-gamma R) and the interaction between Jak1, Jak2, and the IFN-gamma R. In this report, we show that binding of IFN-gamma to HeLa… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

Metastatic Melanoma Cells Evade Immune Detection by Silencing STAT1

International journal of molecular sciences • 2015
View 13 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…