Interferon-gamma induces the expression of immediate early genes c-fos and c-jun in astrocytes.

@article{Rubio1997InterferongammaIT,
  title={Interferon-gamma induces the expression of immediate early genes c-fos and c-jun in astrocytes.},
  author={N. Sanchez Rubio},
  journal={Immunology},
  year={1997},
  volume={91 4},
  pages={560-4}
}
The expression of the proto-oncogenes, c-fos and c-jun, in cultured mouse astrocytes and its induction by the potent astrocyte activator interferon-gamma (IFN-gamma), were examined by Northern blot and flow cytometry. Both proto-oncogenes were induced in a dose-dependent manner, peaking around 100 U/ml of IFN-gamma. The kinetics of expression is very transient for c-fos, reaching a maximum at 30 min and decreasing rapidly thereafter. The c-jun remained high throughout the stages analysed… CONTINUE READING