Interferon gamma induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway.

@article{Song2005InterferonGI,
  title={Interferon gamma induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway.},
  author={Jin Ho Song and Chen Xu Wang and Doyoun K Song and Peng Wang and Ashfaq Shuaib and C. L. Hao},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 13},
  pages={
          12896-901
        }
}
Interferon gamma (IFN-gamma) is a cytokine predominantly involved in antiproliferative and antiviral responses, immune surveillance, and tumor suppression. However, it has been shown that IFN-gamma is also involved in central nervous system development. Here we studied the underlying mechanism for IFN-gamma-induced neuronal differentiation using the human neuroblastoma Paju cell line. Our results indicate that IFN-gamma treatment led to neurite outgrowth followed by growth arrest in the G1… CONTINUE READING

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