Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine.

@article{Kremsner1992InterferongammaIL,
  title={Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine.},
  author={Peter Gottfried Kremsner and Stefan Neifer and M. Ferreira Chaves and Roger Rudolph and Ulrich Bienzle},
  journal={European journal of immunology},
  year={1992},
  volume={22 11},
  pages={2873-8}
}
A combination therapy was tested consisting of chloroquine and interferon-gamma (IFN-gamma) in the late phase of blood-stage Plasmodium vinckei malaria in BALB/c mice. When mice were treated with three times 300 micrograms chloroquine at 24-h intervals starting at a parasitemia of 30%-50%, only 5 of 14 mice (36%) died 2-4 days after initiation of therapy. However, when infected mice received chloroquine plus 1 microgram IFN-gamma at the same time, 14 of 18 mice (78%) died 0.5-3 days after start… CONTINUE READING
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