Interferon-gamma-induced interferon regulatory factor-1 (IRF-1) expression in rodent and human islet cells precedes nitric oxide production.

@article{Flodstrm1997InterferongammainducedIR,
  title={Interferon-gamma-induced interferon regulatory factor-1 (IRF-1) expression in rodent and human islet cells precedes nitric oxide production.},
  author={Malin Flodstr{\"o}m and Decio L. Eizirik},
  journal={Endocrinology},
  year={1997},
  volume={138 7},
  pages={2747-53}
}
The radical nitric oxide (NO) may be a mediator of beta-cell damage in IDDM. The cytokines IFN-gamma and IL-1beta are required for expression of the enzyme nitric oxide synthase (iNOS), and NO production by human pancreatic islets. In this study, possible mechanisms by which IFN-gamma participates in iNOS messenger RNA (mRNA) expression were evaluated in both rodent and human islets cells. Addition of IFN-gamma, before or after arrest of IL-1beta-induced iNOS gene transcription by actinomycin D… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

The Role of Nitric Oxide Synthase in Post-Operative Hyperglycaemia

The Libyan journal of medicine • 2008
View 9 Excerpts
Highly Influenced

Toll-like receptor 4 suppression leads to islet allograft survival.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…