Interferon-gamma-induced degradation of tryptophan by human cells in vitro.

@article{Werner1987InterferongammainducedDO,
  title={Interferon-gamma-induced degradation of tryptophan by human cells in vitro.},
  author={Ernst R Werner and Monica Hirsch-Kauffmann and Dietmar Fuchs and Asno Hausen and Gilbert Reibnegger and Manfred Schweiger and Helmut Wachter},
  journal={Biological chemistry Hoppe-Seyler},
  year={1987},
  volume={368 10},
  pages={1407-12}
}
Several human cells were investigated for their ability to degrade tryptophan and to synthesize neopterin upon induction by interferon-gamma (500 units/ml for 48 h). Concentrations of tryptophan, kynurenine, 3-hydroxykynurenine, anthranilic acid, 3-hydroxyanthranilic acid, 7,8-dihydroneopterin and neopterin were assessed in the culture supernatants by HPLC. Fibroblasts, A-22 arachnoidea, HK-2351 scalp, T-2346 meningeom and HeLa cervical carcinoma cells but not HL-60 promyelocytic leukaemia… CONTINUE READING

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