Interferon-gamma induced cell death in a cultured human salivary gland cell line.

@article{Wu1996InterferongammaIC,
  title={Interferon-gamma induced cell death in a cultured human salivary gland cell line.},
  author={Ava J Wu and Zhi Jian Chen and Maria G Tsokos and Brian C. O'Connell and Indu S Ambudkar and B J Baum},
  journal={Journal of cellular physiology},
  year={1996},
  volume={167 2},
  pages={297-304}
}
Increased levels of several cytokines, including interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha), have been demonstrated in the salivary gland microenvironment of patients with Sjögren's syndrome (SS). How these cytokines may be contributing to the pathogenesis of the disease is not well understood. This study examined the role of IFN-gamma +/- TNF-alpha on cellular death in a cultured human salivary gland cell line (HSG). Cells treated long-term with IFN-gamma +/- TNF… CONTINUE READING

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