Interferon-gamma-induced calcium influx in T lymphocytes of multiple sclerosis and rheumatoid arthritis patients: a complementary mechanism for T cell activation?

@article{Buntinx2002InterferongammainducedCI,
  title={Interferon-gamma-induced calcium influx in T lymphocytes of multiple sclerosis and rheumatoid arthritis patients: a complementary mechanism for T cell activation?},
  author={Mieke Buntinx and Marcel Ameloot and Paul Steels and P. Janssen and Robert Medaer and Piet P. Geusens and Jef Raus and Piet Stinissen},
  journal={Journal of neuroimmunology},
  year={2002},
  volume={124 1-2},
  pages={70-82}
}
Autoreactive T lymphocytes are considered to play a crucial role in orchestrating a chronic inflammation in the central nervous system (CNS) of multiple sclerosis (MS) patients and in the joints of rheumatoid arthritis (RA) patients. However, it has been suggested that the majority of T cells in the immune infiltrate are nonspecifically recruited into the CNS and into the inflamed joint. In addition, several lines of evidence suggest an important role for interferon-gamma (IFN-gamma) in the… CONTINUE READING