Interferon-gamma enhances susceptibility of cervical cancer cells to lysis by tumor-specific cytotoxic T cells.

@article{Street1997InterferongammaES,
  title={Interferon-gamma enhances susceptibility of cervical cancer cells to lysis by tumor-specific cytotoxic T cells.},
  author={Dean Trench Street and Andreas M Kaufmann and Aislinn Vaughan and Susan Gross Fisher and Mark Hunter and Carola Schreckenberger and Ronald K. Potkul and Lutz Gissmann and Ling Qiao},
  journal={Gynecologic oncology},
  year={1997},
  volume={65 2},
  pages={265-72}
}
Recently we have demonstrated that tumor-specific cytotoxic T lymphocytes (CTLs) can be activated by cervical carcinoma cells expressing the costimulatory molecule CD80, which may be used as a therapeutic vaccine for patients with cervical cancer. For activated CTLs to be effective, appropriate amounts of MHC class I expression are required on target tumor cells. In this study, we found that some cervical carcinoma cells expressed only low levels of MHC class I and adhesion molecules such as… CONTINUE READING
Highly Cited
This paper has 183 citations. REVIEW CITATIONS

Topics

Statistics

020406080'01'03'05'07'09'11'13'15'17
Citations per Year

183 Citations

Semantic Scholar estimates that this publication has 183 citations based on the available data.

See our FAQ for additional information.