Interferon-gamma enhances resolution of herpes simplex virus type 2 infection of the murine genital tract.

@article{Milligan1997InterferongammaER,
  title={Interferon-gamma enhances resolution of herpes simplex virus type 2 infection of the murine genital tract.},
  author={Gregg N. Milligan and David I. Bernstein},
  journal={Virology},
  year={1997},
  volume={229 1},
  pages={259-68}
}
The requirement for interferon-gamma (IFN gamma) in resolution of an HSV-2 vaginal infection and the cellular sources of this cytokine in the vaginal mucosa were assessed. IFN gamma levels in vaginal secretions peaked on Days 2 and 5 following HSV-2 inoculation. Natural killer (NK) cell depletion greatly diminished the early production of IFN gamma but had no significant effect on the rate of virus clearance. CD4+ T cells were primarily responsible for the second peak of IFN gamma levels and… CONTINUE READING
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