Interferon-gamma elicits arteriosclerosis in the absence of leukocytes.

  title={Interferon-gamma elicits arteriosclerosis in the absence of leukocytes.},
  author={George Tellides and Denis A. Tereb and Nancy Coula Kirkiles-Smith and Richard W. Kim and Jean H. Wilson and Jeffrey S. Schechner and Marc I. Lorber and Jordan S Pober},
  volume={403 6766},
Atherosclerosis and post-transplant graft arteriosclerosis are both characterized by expansion of the arterial intima as a result of the infiltration of mononuclear leukocytes, the proliferation of vascular smooth muscle cells (VSMCs) and the accumulation of extracellular matrix. They are also associated with the presence of the immunomodulatory cytokine interferon-gamma (IFN-gamma). Moreover, in mouse models of atheroma formation or allogeneic transplantation, the serological neutralization or… CONTINUE READING


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