Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells.

@article{Schwinn2009InterferongammaDN,
  title={Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells.},
  author={Nicole Schwinn and Daria Vokhminova and Antje Sucker and Sonja Textor and Sandra Striegel and Iris Moll and Norman Nausch and Jochen Tuettenberg and Alexander Steinle and Adelheid Cerwenka and Dirk Schadendorf and Annette Paschen},
  journal={International journal of cancer},
  year={2009},
  volume={124 7},
  pages={1594-604}
}
NKG2D operates as an activating receptor on natural killer (NK) cells and costimulates the effector function of alphabeta CD8(+) T cells. Ligands of NKG2D, the MHC class I chain-related (MIC) and UL16 binding protein (ULBP) molecules, are expressed on a variety of human tumors, including melanoma. Recent studies in mice demonstrated that NKG2D mediates tumor immune surveillance, suggesting that antitumor immunity in humans could be enhanced by therapeutic manipulation of NKG2D ligand (NKG2DL… CONTINUE READING
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