Interferon-gamma-dependent infiltration of human T cells into neuroblastoma tumors in vivo.

@article{Reid2009InterferongammadependentIO,
  title={Interferon-gamma-dependent infiltration of human T cells into neuroblastoma tumors in vivo.},
  author={Gregor S D Reid and Xiaochuan Shan and Christina M. Coughlin and Wiem Lassoued and Bruce R. Pawel and Leonard H. Wexler and Carol J. Thiele and Maria G Tsokos and Jack L. Pinkus and Geraldine S. Pinkus and Stephan A. Grupp and Robert H. Vonderheide},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 21},
  pages={6602-8}
}
PURPOSE To investigate the impact of interferon-gamma-mediated upregulation of major histocompatibility complex class I expression on tumor-specific T-cell cytotoxicity and T-cell trafficking into neuroblastoma tumors in vivo. EXPERIMENTAL DESIGN Restoration of major histocompatibility complex class I expression by interferon-gamma treatment enhances killing of neuroblastoma cells. To understand the potential of this approach in vivo, we developed a novel model of neuroblastoma in which NOD… CONTINUE READING

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