Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.

  title={Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.},
  author={Kelly M Cautivo and Peri Matatia and Carlos O. Lizama and Nicholas M. Mroz and Madelene W. Dahlgren and Xiaofei Yu and Julia Sbierski-Kind and Marcela T. Taruselli and Jeremy F. Brooks and Adam K. Wade-Vallance and Sofia E. Caryotakis and Anthony Chang and Hong-Erh Liang and Julie Zikherman and Richard M. Locksley and Ari B. Molofsky},
  volume={55 2},

Mucosal-associated invariant T cells repress group 2 innate lymphoid cells in Alternaria alternata-induced model of allergic airway inflammation

It is concluded that MAIT cells played a crucial role in suppressing the cytokine-producing capacity of I LC2s and ILC2 proliferation, that ultimately led to decrease in the allergic airway inflammation.

Tissue Resident and Migratory Group 2 Innate Lymphoid Cells

Recent findings on ILC2 migration, including migration within, into and out of tissues during inflammation, are reviewed.

IL-33 and the PKA Pathway Regulate ILC2 Populations Expressing IL-9 and ST2

ILC2s in mice infected with N. brasiliensis can be classified into different groups based on the expression of IL-9 and ST2, providing further evidence of a high heterogeneity between ILC2 subsets in a context dependent manner and calls for careful consideration when choosing the markers to identify these cells in vivo.

A single-cell map of vascular and tissue lymphocytes identifies proliferative TCF-1+ human innate lymphoid cells

A comprehensive map reveals the proliferative topography of human ILCs, linking cell migration and spatial compartmentalization with cell division.

Differential regulation of lineage-determining transcription factor expression in innate lymphoid cell and adaptive T helper cell subsets

This review discusses the functions of lineage-related cis-regulatory elements in inducing T-bet, GATA3 or RORγt expression based on the genetic evidence provided in recent publications and discusses the possible mechanisms and physiological importance of regulating LDTF dynamic expression during ILC development and activation.

Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma

The role of three T helper subsets in the pathogenesis of asthma from different stages is reviewed, highlighting timing is everything in the immune system.

Heartbreakers or Healers? Innate Lymphoid Cells in Cardiovascular Disease and Obesity

The evidence for pathological and protective roles of ILCs in CVD, and its associated risk factor, obesity, are discussed.