Interferon gamma and tumour necrosis factor alpha are overexpressed in bone marrow T lymphocytes from paediatric patients with aplastic anaemia.

@article{Dufour2001InterferonGA,
  title={Interferon gamma and tumour necrosis factor alpha are overexpressed in bone marrow T lymphocytes from paediatric patients with aplastic anaemia.},
  author={Carlo Dufour and Anna Corcione and Johanna Svahn and Riccardo Haupt and Nicoletta Battilana and Vito Pistoia},
  journal={British journal of haematology},
  year={2001},
  volume={115 4},
  pages={1023-31}
}
Twelve paediatric patients with aplastic anaemia and two groups of normal control subjects underwent flow cytometric analysis for intracytoplasmic expression of gamma interferon (gamma-IFN) and tumour necrosis factor alpha (TNF-alpha) in bone marrow and peripheral blood CD4+ and CD8+ cells. The same cytokines were tested, by immunoassay, in culture supernatants from unstimulated bone marrow mononuclear cells (MNCs). Marrow CD4+ and CD8+ cells expressing gamma-IFN and TNF-alpha were… CONTINUE READING

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