Interferon gamma-1b in the treatment of compensatory anti-inflammatory response syndrome. A new approach: proof of principle.

@article{Kox1997InterferonGI,
  title={Interferon gamma-1b in the treatment of compensatory anti-inflammatory response syndrome. A new approach: proof of principle.},
  author={W J Kox and Roger C. Bone and Dietmar Krausch and W D Doecke and Stephan Kox and Helmar Wauer and Karl Egerer and Susanne Querner and Khusru Asadullah and R von Baehr and Hans Dieter Volk},
  journal={Archives of internal medicine},
  year={1997},
  volume={157 4},
  pages={389-93}
}
BACKGROUND Immunoparalysis is defined as a decrease in the level of HLA-DR expression on monocytes during the course of sepsis. OBJECTIVE To evaluate whether interferon gamma-1b has an immunoregulatory effect in patients with immunoparalysis during the compensatory anti-inflammatory response syndrome. METHODS Of the patients admitted consecutively to the intensive care unit for the management of sepsis, 10 received interferon gamma-1b, 100 micrograms per 0.5 mL, after confirmation of HLA-DR… CONTINUE READING

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