Interferon gamma/interleukin-4 modulation, anti-inflammatory and antioxidant effects of hesperidin in complete Freund’s adjuvant (CFA)-induced arthritis model of rats

@article{Adefegha2020InterferonGM,
  title={Interferon gamma/interleukin-4 modulation, anti-inflammatory and antioxidant effects of hesperidin in complete Freund’s adjuvant (CFA)-induced arthritis model of rats},
  author={Stephen Adeniyi Adefegha and N. Bottari and D. Leal and C. M. Andrade and Maria Rosa Schetinger},
  journal={Immunopharmacology and Immunotoxicology},
  year={2020},
  volume={42},
  pages={509 - 520}
}
Abstract Background This study sought to assess the effect of hesperidin on serum inflammatory cytokines and oxidative damage in liver of complete Freund’s adjuvant (CFA)-induced arthritic rats. Method Fifty-six adult female Wistar rats (220–250 g) were acclimatized for two weeks. Intraplantar injection of CFA was done for the induction of arthritis and confirmed on the 14th day prior to oral administration of 40 and 80 mg/kg of hesperidin or dexamethasone for 45 days. Result The result showed… Expand
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Suppression of adjuvant arthritis by hesperidin in rats and its mechanisms
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