Interferon combination therapy for HIV/hepatitis C virus coinfection.

  title={Interferon combination therapy for HIV/hepatitis C virus coinfection.},
  author={A. Sadananda Chary and Mark Holodniy},
  volume={3 9},
IFN-α has been the cornerstone of chronic hepatitis C virus (HCV) treatment for over a decade. Yet, rates of sustained virologic response of HCV infection to interferon-based therapy, particularly in difficult-to-treat populations, have been disappointingly low. This is particularly true in HIV/HCV coinfection, in which less than a third of patients typically respond to therapy. New HCV protease inhibitors, most of which will need to be administered with pegylated interferon, are in development… CONTINUE READING