Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply

@inproceedings{Dragin2012InterferonBT,
  title={Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply},
  author={Loic Lionel Dragin and Laura Anh Nguyen and Hichem Lahouassa and Ad{\`e}le Sourisce and Baek ki Kim and Bertha C{\'e}cilia Ramirez and Florence Margottin-Goguet},
  booktitle={Retrovirology},
  year={2012}
}
Interferon-α (IFN-α) is an essential mediator of the antiviral response, which potently inhibits both early and late phases of HIV replication. The SAMHD1 deoxynucleoside triphosphate (dNTP) hydrolase represents the prototype of a new antiviral strategy we referred to as “nucleotide depletion”. SAMHD1 depletes dNTP levels in myeloid cells below those required for optimal synthesis of HIV viral DNA. HIV-2 and its SIVsm and SIVmac close relatives encode a protein termed Vpx, which counteracts… CONTINUE READING
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