Interferon-beta treatment and active replication of the JC virus in relapsing-remitting multiple sclerosis patients.

@article{AlvarezLafuente2007InterferonbetaTA,
  title={Interferon-beta treatment and active replication of the JC virus in relapsing-remitting multiple sclerosis patients.},
  author={Roverto Alvarez-Lafuente and Marta Garc{\'i}a-Montojo and V Fern{\'a}ndez Garc{\'i}a de las Heras and Manuel Bartolom{\'e} and R. X. Arroyo},
  journal={European journal of neurology},
  year={2007},
  volume={14 2},
  pages={233-6}
}
We analyzed the effect of beta-interferon (beta-IFN) treatment over the active replication of JC virus (JCV) through the evaluation of JCV DNA prevalence and viral load in peripheral blood mononuclear cells (PBMCs) and serum samples, and mRNA prevalence and viral load, in relapsing-remitting multiple sclerosis (RRMS) patients. DNA extracted from PBMCs and serum, and mRNA extracted from PBMCs were analyzed in 146 RRMS patients (73 treated with beta-IFN, and 73 untreated patients), and 73 matched… CONTINUE READING

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