Interferon-beta specifically inhibits interferon-gamma-induced class II major histocompatibility complex gene transcription in a human astrocytoma cell line.

@article{Ransohoff1991InterferonbetaSI,
  title={Interferon-beta specifically inhibits interferon-gamma-induced class II major histocompatibility complex gene transcription in a human astrocytoma cell line.},
  author={Richard M Ransohoff and Chalasani Devajyothi and Melinda L. Estes and George E Babcock and Richard A. Rudick and Elliot M. Frohman and Barbara P. Barna},
  journal={Journal of neuroimmunology},
  year={1991},
  volume={33 2},
  pages={103-12}
}
We established cultures of human astrocytes and astrocytoma cells from surgical specimens, to study regulation of class II major histocompatibility (MHC) complex antigen expression by interferons. Using these cultures we previously showed that expression of the class II MHC determinant HLA-DR could be induced by interferon-gamma and this induction was inhibited by interferon-beta. In this report, we extend these observations by showing that the inhibitory effect of interferon-beta on interferon… CONTINUE READING

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