Interferon-beta is activated by hepatitis C virus NS5B and inhibited by NS4A, NS4B, and NS5A.

@article{Moriyama2007InterferonbetaIA,
  title={Interferon-beta is activated by hepatitis C virus NS5B and inhibited by NS4A, NS4B, and NS5A.},
  author={Masaru Moriyama and Naoya Kato and Motoyuki Otsuka and Run-Xuan Shao and Hiroyoshi Taniguchi and Takao Kawabe and Masao Omata},
  journal={Hepatology international},
  year={2007},
  volume={1 2},
  pages={
          302-10
        }
}
Innate immunity is part of the antiviral response. Interferon (IFN)-beta plays a leading role in this system. To investigate the influence of hepatitis C virus (HCV) on innate immunity, we examined the effect of viral proteins on IFN-beta induction. HepG2 cells were co-transfected with plasmids for seven HCV proteins (core protein, NS2, NS3, NS4A, NS4B, NS5A, and NS5B) and the IFN-beta promoter luciferase. Toll-like receptor (TLR) 3 and Toll/IL-1 receptor domain-containing adapter inducing IFN… CONTINUE READING
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