Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity.

@article{Krumbholz2008InterferonbetaIB,
  title={Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity.},
  author={Markus Krumbholz and Hette Faber and Florian Steinmeyer and L Hoffmann and Tania Kuempfel and Hannah Pellkofer and Tobias J Derfuss and Corina Maria Ionescu and Michaela Starck and Christian Hafner and Reinhard Hohlfeld and Edgar Meinl},
  journal={Brain : a journal of neurology},
  year={2008},
  volume={131 Pt 6},
  pages={1455-63}
}
B cells are increasingly recognized as major players in multiple sclerosis pathogenesis. The BAFF/APRIL system is crucial for B cell homoeostasis and may drive B cell-dependent autoimmunity. We asked whether this system is affected by Interferon (IFN)-beta therapy. We analysed transcription of the ligands (BAFF, APRIL, TWE-PRIL) and the corresponding receptors (BAFF-R, TACI and BCMA) by TaqMan-PCR ex vivo in whole blood and in immune cell subsets purified from IFN-beta-treated multiple… CONTINUE READING