Interferon-beta fails to protect in a model of transient focal stroke.

  title={Interferon-beta fails to protect in a model of transient focal stroke.},
  author={Carolina Magdalene Maier and Fengshan Yu and Tatsuro Nishi and Stephanie J Lathrop and Pak Hoo Chan},
  volume={37 4},
BACKGROUND AND PURPOSE Compelling evidence supporting the role of inflammation in the development of cerebral infarction has focused attention on the potential of antiinflammatory treatment strategies for stroke. Interferon (IFN)-beta, an immunomodulatory agent approved for treatment of multiple sclerosis, is being evaluated in a phase I clinical trial in acute ischemic stroke. In the present study, we evaluated the effects of wild-type rat IFN-beta and its pegylated counterpart (PEG-IFN-beta… CONTINUE READING
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