Interferon as a macrophage activating factor. I. Enhancement of cytotoxicity by fresh and matured human monocytes in the absence of other soluble signals.


The cytolytic activity of human peripheral blood monocytes in vitro against K-562 human leukaemic target cells was stimulated by human fibroblast (beta-) and leucocyte (alpha-) interferon (IFN). Stimulation was by up to several times the corresponding control activity, and was observed with freshly isolated monocytes, and with monocytes cultured for various… (More)