Interferon-and interleukin-4 reciprocally regulate CD 8 expression in CD 8 T cells

@inproceedings{Apte2008InterferonandIR,
  title={Interferon-and interleukin-4 reciprocally regulate CD 8 expression in CD 8 T cells},
  author={Simon H Apte and Adriana Baz and Penny L. Groves and Anne Kelso and Norbert Alexander Kienzle},
  year={2008}
}
The CD8 co-receptor can modulate CD8 T cell function through its contributions to T cell receptor (TCR) binding and signaling. Here we show that IFNand IL-4 exert opposing effects on the expression of CD8 mRNA and surface CD8 protein during CD8 T cell activation. IL-4 caused down-regulation of surface CD8 on ovalbumin (OVA)257–264-specific TCR-transgenic OT-I CD8 T cells activated with OVA257–264-coated antigen presenting cells or polyclonal stimuli, and on wild type CD8 T cells activated with… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation

SR Jenkinson
  • J Exp Med
  • 2007
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Characterization of recombinant human interleukin-2 with micromethods.

  • Journal of chromatography
  • 1985
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Negative regulation of CD8 expression via CD8 enhancer-mediated recruitment of the zinc finger protein MAZR

I Bilic
  • Nat Immunol
  • 2006
VIEW 1 EXCERPT