Interferon-alpha stimulates production of interleukin-10 in activated CD4+ T cells and monocytes.

  title={Interferon-alpha stimulates production of interleukin-10 in activated CD4+ T cells and monocytes.},
  author={M Javad Aman and Theresa Tretter and Ilona Eisenbeis and Gesine Bug and Thorsten Decker and Walter Erich Aulitzky and Herbert Tilg and Christoph Huber and Christian Peschel},
  volume={87 11},
In the present study, we investigated the effect of interferon-alpha (IFN-alpha) on the expression of interleukin-10 (IL-10) mRNA and protein synthesis in human monocytes and CD4+ T cells. In mononuclear cells, IFN-alpha induced expression of IL-10 mRNA and further enhanced lipopolysaccharide (LPS)-stimulated IL-10 expression. In purified monocytes, a strong expression of IL-10 mRNA induced by LPS was not further enhanced by IFN-alpha. In highly purified CD4+ T cells, IFN-alpha upregulated IL… CONTINUE READING
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