Interferon-alpha promotes survival of human primary B-lymphocytes via phosphatidylinositol 3-kinase.

@article{Ruuth2001InterferonalphaPS,
  title={Interferon-alpha promotes survival of human primary B-lymphocytes via phosphatidylinositol 3-kinase.},
  author={Kristina Ruuth and Lennart Carlsson and Bengt Hallberg and Erik Lundgren},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={284 3},
  pages={583-6}
}
Signaling pathways for the antiviral and antiproliferative biological effects of type I interferons (IFN) are well established. In this report we demonstrate a novel signaling pathway for IFN-alpha, as it induced rapid phosphorylation of both PKB/Akt and its substrate forkhead. The PI3-kinase inhibitor LY294002 abolished these phosphorylations. PI3-kinase… CONTINUE READING