Interferon-alpha in the treatment of high-risk haemangiomas in infants.

Abstract

BACKGROUND Haemangiomas are benign tumours that may occasionally compress vital structures, or cause consumptive coagulopathy and heart failure. We describe our recent experience with interferon-alpha as a treatment modality for high-risk haemangiomas. PATIENTS AND METHODS Eight children with high-risk haemangiomas were treated with interferon-alpha, six of which had failed previous steroid therapy. RESULT Seven children responded to interferon therapy, one boy with a liver haemangioma died. Mild leucopenia and granulocytopenia were observed in all treated patients. Neurotoxicity occurred in 3 patients and was the most frequent serious complication. CONCLUSION Interferon-alpha is an effective treatment modality for high-risk haemangiomas in children, especially in steroid-resistant patients. The most serious complication was early neurological toxicity.

Cite this paper

@article{SzymikKantorowicz2005InterferonalphaIT, title={Interferon-alpha in the treatment of high-risk haemangiomas in infants.}, author={Sabina Szymik-Kantorowicz and Krzysztof Kobylarz and Miroslaw Krysta and Wojciech G{\'o}recki and A Bysiek and Edward J Celmer and Maria Dzierzega}, journal={European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie}, year={2005}, volume={15 1}, pages={11-6} }