Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress.

Abstract

Despite substantial advances in the research exploring the pathogenesis of Type 1 Diabetes (T1D), the pathophysiological mechanisms involved remain unknown. We hypothesized in this study that interferon alpha (IFNα) participates in the early stages of T1D development by triggering endoplasmic reticulum (ER) stress. To verify our hypothesis, human islets and… (More)
DOI: 10.1016/j.jaut.2017.02.002

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Cite this paper

@article{Lombardi2017InterferonAI, title={Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress.}, author={Angela Lombardi and Yaron Tomer}, journal={Journal of autoimmunity}, year={2017}, volume={80}, pages={48-55} }