Interferon-alpha causes neuronal dysfunction in encephalitis.

  title={Interferon-alpha causes neuronal dysfunction in encephalitis.},
  author={Andrew R. Sas and Heather A. Bimonte-Nelson and Corigan Thetford Smothers and John P. L. Woodward and William R Tyor},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={29 12},
Interferon-alpha (IFNalpha) is a pleomorphic cytokine produced by nucleated cells in response to viral infection. In patients, treatment with IFNalpha has side effects including cognitive impairment resembling subcortical dementia, which is a hallmark of human immunodeficiency virus (HIV)-associated dementia (HAD). IFNalpha is increased in the CSF of HAD patients compared with HIV patients without dementia. In this study, blocking IFNalpha in a HIV encephalitis (HIVE) mouse model with… CONTINUE READING
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