Interferon-alpha but not AZT suppresses HIV expression in chronically infected cell lines.

@article{Poli1989InterferonalphaBN,
  title={Interferon-alpha but not AZT suppresses HIV expression in chronically infected cell lines.},
  author={Guido Poli and Jan Marc Orenstein and Audrey L. Kinter and Thomas M. Folks and Anthony S. Fauci},
  journal={Science},
  year={1989},
  volume={244 4904},
  pages={575-7}
}
Promonocytic (U1) and T lymphocytic (ACH-2) cell lines chronically infected with human immunodeficiency virus type 1 (HIV-1) constitutively express low levels of virus, but expression can be induced by phorbol esters and cytokines. Whereas ACH-2 cells produce infectious virions, U1 cells produce defective, noninfectious particles. Although 3'-azido-3'-deoxythimidine (AZT) prevented acute HIV infection of susceptible cells, it did not prevent the induction of HIV expression in the infected cell… CONTINUE READING

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