Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection.

Abstract

Interferon (IFN)-alpha/beta-mediated negative regulation of interleukin 12 (IL-12) and IFN-gamma proteins is reported here. Both IFN-alpha and IFN-beta inhibited fixed Staphylococcus aureus Cowan strain induction of IL-12 and IFN-gamma production by mouse splenic leukocytes in culture. Extended studies with IFN-alpha demonstrated that inhibition was at the… (More)

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@article{Cousens1997InterferonalphabetaIO, title={Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection.}, author={Leslie P. Cousens and Jordan S Orange and Helen C Su and Christine A. Biron}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1997}, volume={94 2}, pages={634-9} }