Interferon-alpha and viral triggers promote functional maturation of human monocyte-derived dendritic cells.

@article{Farkas2008InterferonalphaAV,
  title={Interferon-alpha and viral triggers promote functional maturation of human monocyte-derived dendritic cells.},
  author={Arp{\'a}d Farkas and Giulia Tonel and Frank O. Nestle},
  journal={The British journal of dermatology},
  year={2008},
  volume={158 5},
  pages={921-9}
}
BACKGROUND Type I interferons (IFNs) play an important role in the pathogenesis of many autoimmune disorders including psoriasis. In the presence of IFN-alpha and granulocyte/macrophage colony-stimulating factor (GM-CSF), monocytes differentiate into dendritic cells (DCs) referred to as IFN-DCs. IFN-DCs potentially mimic DC populations involved in psoriasis and express a wide range of Toll-like receptor (TLR) subtypes. OBJECTIVES Recently, it was shown that single-stranded RNA (ssRNA… CONTINUE READING

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