Interferon-alpha and dexamethasone inhibit adhesion of T cells to endothelial cells and synovial cells.

@article{Eguchi1992InterferonalphaAD,
  title={Interferon-alpha and dexamethasone inhibit adhesion of T cells to endothelial cells and synovial cells.},
  author={Kenji Eguchi and Atsushi Kawakami and Masahiro Nakashima and Hiroyuki Ida and Sohko Sakito and Naoki Matsuoka and Kunihiko Terada and Masatoshi Sakai and Yojiro Kawabe and Takaaki Fukuda},
  journal={Clinical and experimental immunology},
  year={1992},
  volume={88 3},
  pages={
          448-54
        }
}
We investigated whether interferon-gamma (IFN-gamma), interferon-alpha (IFN-alpha) and glucocorticoids affected the adhesion of T cells to human umbilical endothelial cells or human synovial cells. About 30% of peripheral blood T cells could bind to unstimulated endothelial cells, but only a few T cells could bind to unstimulated synovial cells. When both endothelial cells and synovial cells were cultured with recombinant IFN-gamma (rIFN-gamma), the percentage of T cell binding to both types of… CONTINUE READING

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