Interferon alpha and alcohol augment nuclear regulatory factor-kappaB activation in HepG2 cells, and interferon alpha increases pro-inflammatory cytokine production.

@article{Szabo2001InterferonAA,
  title={Interferon alpha and alcohol augment nuclear regulatory factor-kappaB activation in HepG2 cells, and interferon alpha increases pro-inflammatory cytokine production.},
  author={Gyongyi Szabo and Donna Catalano and Gary Bellerose and Pranoti Mandrekar},
  journal={Alcoholism, clinical and experimental research},
  year={2001},
  volume={25 8},
  pages={1188-97}
}
BACKGROUND The mechanisms for decreased therapeutic response to IFNalpha in chronic hepatitis C patients with alcohol are unknown. We investigated the hypothesis that IFNalpha and alcohol regulate cells both in the liver parenchyma and the immune system. METHODS We used the hepatocellular carcinoma cells (HepG2) to determine if IFNalpha (500-10,000 U/ml) or ethanol (25-100 mM) modulates NF-kB activation alone or in combination with TNFalpha (0.1-20 microg/ml) as determined in electromobility… CONTINUE READING