Interferon-alpha and 5-fluorouracil therapy in patients with metastatic renal cell cancer: an open multicenter trial. The Japanese Study Group Against Renal Cancer.

@article{Igarashi1999InterferonalphaA5,
  title={Interferon-alpha and 5-fluorouracil therapy in patients with metastatic renal cell cancer: an open multicenter trial. The Japanese Study Group Against Renal Cancer.},
  author={Tatsuo Igarashi and Ken Marumo and Tetsuro Onishi and Mikio Kobayashi and Keisuke Aiba and Tomoyasu Tsushima and Seiichiro Ozono and Yoshihiko Tomita and Toshiro Terachi and Yoshiaki Satomi and Juichi Kawamura},
  journal={Urology},
  year={1999},
  volume={53 1},
  pages={53-9}
}
OBJECTIVES Recent clinical trials have implied the cytotoxic and antiproliferative effects of combining 5-fluorouracil and interferon-alpha in the treatment of metastatic renal cell cancer. We therefore conducted an open multicenter trial to test the efficacy of such a combination on this cancer. METHODS Human lymphoblastoid interferon (3 MIU per patient) was administered subcutaneously three times weekly for 12 weeks, while 5-fluorouracil was administered (600 mg/m2/day) as a continuous… CONTINUE READING