Interferon-alpha A/D blocks an increase in Fc receptors of a human promyelocytic leukemia cell line (HL-60) induced by other recombinant interferons.


The effect of recombinant hybrid interferon (IFN)-alpha A/D either alone or in combination with retinoic acid (RA) on induction of differentiation of the human promyelocytic leukemia cell line HL-60 was studied. The combination of 10 nM RA and IFN-alpha A/D at concentrations of 120 units/ml and higher induces differentiation into cells having many monocytic… (More)


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