Interferon alpha (IFN) treatment of bone marrow stroma inhibits haematopoesis.

  title={Interferon alpha (IFN) treatment of bone marrow stroma inhibits haematopoesis.},
  author={Christoph Kasper and Anna L{\"u}bking and Dietrich W. Beelen and Ullrich D{\"u}hrsen},
  journal={Leukemia research},
  volume={28 11},
Prolonged pre-transplant IFN administration in patients with chronic myeloid leukaemia has been associated with an increased risk of fatal transplant-related complications and an inferior outcome after allogeneic bone marrow transplantation. Using a two-stage long-term bone marrow culture as an in vitro model we were able to show a negative effect of higher doses of IFN pre-treatment of bone marrow stroma on haematopoesis. This correlated with a decline in the number of monocytes-macrophages… CONTINUE READING