Interferon alpha (IFN) treatment of bone marrow stroma inhibits haematopoesis.

@article{Kasper2004InterferonA,
  title={Interferon alpha (IFN) treatment of bone marrow stroma inhibits haematopoesis.},
  author={Christoph Kasper and Anna L{\"u}bking and Dietrich W. Beelen and Ullrich D{\"u}hrsen},
  journal={Leukemia research},
  year={2004},
  volume={28 11},
  pages={1217-20}
}
Prolonged pre-transplant IFN administration in patients with chronic myeloid leukaemia has been associated with an increased risk of fatal transplant-related complications and an inferior outcome after allogeneic bone marrow transplantation. Using a two-stage long-term bone marrow culture as an in vitro model we were able to show a negative effect of higher doses of IFN pre-treatment of bone marrow stroma on haematopoesis. This correlated with a decline in the number of monocytes-macrophages… CONTINUE READING