Interferon-alpha–induced changes in tryptophan metabolism relationship to depression and paroxetine treatment
@article{Capuron2003InterferonalphainducedCI, title={Interferon-alpha–induced changes in tryptophan metabolism relationship to depression and paroxetine treatment}, author={Lucile Capuron and Gabriele Neurauter and Dominique L. Musselman and David H. Lawson and Charles B. Nemeroff and Dietmar Fuchs and Andrew H. Miller}, journal={Biological Psychiatry}, year={2003}, volume={54}, pages={906-914} }
455 Citations
IDO and interferon-α-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity
- Biology, PsychologyMolecular Psychiatry
- 2005
A role for IDO activity in the pathophysiology of IFN-α-induced depressive symptoms is supported, through its induction of neurotoxic KYN metabolites.
ORIGINAL RESEARCH ARTICLE IDO and interferon-a-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity
- Biology, Psychology
- 2005
A role for IDO activity in the pathophysiology of IFN-a-induced depressive symptoms is supported, through its induction of neurotoxic KYN metabolites.
Interferon-α Influences Tryptophan Metabolism without Inducing Psychiatric Side Effects
- Psychology, MedicineNeuropsychobiology
- 2007
IFN-α was found to alter TRP metabolism without inducing psychiatric side effects, and a possible relationship between TRp metabolism and depression was not substantiated by this study.
CSF Concentrations of Brain Tryptophan and Kynurenines during Immune Stimulation with IFN-alpha: Relationship to CNS Immune Responses and Depression
- Biology, PsychologyMolecular Psychiatry
- 2010
Peripheral administration of IFN-α activated IDO in concert with central cytokine responses, resulting in increased brain KYN and QUIN, which correlated with depressive symptoms.
Interferon-alpha treatment induces depression-like behaviour accompanied by elevated hippocampal quinolinic acid levels in rats
- Biology, PsychologyBehavioural Brain Research
- 2015
Depressive symptoms following interferon-α therapy: mediated by immune-induced reductions in brain-derived neurotrophic factor?
- Biology, PsychologyThe international journal of neuropsychopharmacology
- 2011
The findings suggest that the effect of IFN-α-induced immune activation on depression may be explained in part by alterations in neuroprotective capacity, reflected by decreases in serum BDNF following IFn-α treatment.
Effects of PEG-interferon alpha plus ribavirin on tryptophan metabolism in patients with chronic hepatitis C.
- Biology, MedicinePharmacological research
- 2011
Insights from interferon-α-related depression for the pathogenesis of depression associated with inflammation
- Biology, MedicineBrain, Behavior, and Immunity
- 2014
Effect of immune activation on the kynurenine pathway and depression symptoms – A systematic review and meta-analysis
- Medicine, PsychologyNeuroscience & Biobehavioral Reviews
- 2020
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