Interferon-alpha–induced changes in tryptophan metabolism relationship to depression and paroxetine treatment

@article{Capuron2003InterferonalphainducedCI,
  title={Interferon-alpha–induced changes in tryptophan metabolism relationship to depression and paroxetine treatment},
  author={Lucile Capuron and Gabriele Neurauter and Dominique L. Musselman and David H. Lawson and Charles B. Nemeroff and Dietmar Fuchs and Andrew H. Miller},
  journal={Biological Psychiatry},
  year={2003},
  volume={54},
  pages={906-914}
}
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IDO and interferon-α-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity
TLDR
A role for IDO activity in the pathophysiology of IFN-α-induced depressive symptoms is supported, through its induction of neurotoxic KYN metabolites.
ORIGINAL RESEARCH ARTICLE IDO and interferon-a-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity
TLDR
A role for IDO activity in the pathophysiology of IFN-a-induced depressive symptoms is supported, through its induction of neurotoxic KYN metabolites.
Interferon-α Influences Tryptophan Metabolism without Inducing Psychiatric Side Effects
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IFN-α was found to alter TRP metabolism without inducing psychiatric side effects, and a possible relationship between TRp metabolism and depression was not substantiated by this study.
CSF Concentrations of Brain Tryptophan and Kynurenines during Immune Stimulation with IFN-alpha: Relationship to CNS Immune Responses and Depression
TLDR
Peripheral administration of IFN-α activated IDO in concert with central cytokine responses, resulting in increased brain KYN and QUIN, which correlated with depressive symptoms.
Interferon-alpha treatment induces depression-like behaviour accompanied by elevated hippocampal quinolinic acid levels in rats
Depressive symptoms following interferon-α therapy: mediated by immune-induced reductions in brain-derived neurotrophic factor?
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The findings suggest that the effect of IFN-α-induced immune activation on depression may be explained in part by alterations in neuroprotective capacity, reflected by decreases in serum BDNF following IFn-α treatment.
Effects of PEG-interferon alpha plus ribavirin on tryptophan metabolism in patients with chronic hepatitis C.
Insights from interferon-α-related depression for the pathogenesis of depression associated with inflammation
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References

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