Interferon alfa therapy for chronic hepatitis B in children: a multinational randomized controlled trial.

@article{Sokal1998InterferonAT,
  title={Interferon alfa therapy for chronic hepatitis B in children: a multinational randomized controlled trial.},
  author={Etienne Sokal and Hari S. Conjeevaram and Eve A. Roberts and Fernando Alvarez and Elana M Bern and Philippe J. Goyens and Philip John Rosenthal and Alain Lachaux and Mark Shelton and Jacques Sarles and Jay H. Hoofnagle},
  journal={Gastroenterology},
  year={1998},
  volume={114 5},
  pages={988-95}
}
BACKGROUND & AIMS Treatment of chronic hepatitis B with interferon alfa is not approved in children. The aim of this study was to evaluate the safety and efficacy of interferon alfa (IFN-alpha) in children with chronic hepatitis B and increased transaminase levels. METHODS Children were given either IFN-alpha2b (6 megaunits/m2 thrice weekly for 24 weeks) or no treatment. Clearance of markers of viral replication was evaluated 24 weeks after therapy and after 48 weeks of observation in… CONTINUE READING

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