Interferon Regulatory Factor 6 is necessary but not sufficient for keratinocyte differentiation

@inproceedings{Biggs2012InterferonRF,
  title={Interferon Regulatory Factor 6 is necessary but not sufficient for keratinocyte differentiation},
  author={Leah C Biggs and Lindsey Rhea and Brian C. Schutte and Martine Dunnwald},
  booktitle={The Journal of investigative dermatology},
  year={2012}
}
Regulation of epidermal proliferation and differentiation is critical for maintenance of cutaneous homeostasis. Interferon Regulatory Factor 6 (Irf6)-deficient mice die perinatally and exhibit ectopic proliferation and defective epidermal differentiation. We sought to determine whether these disruptions of epidermal function were cell autonomous, and used embryonic Irf6(-/-) keratinocytes to understand the specific role of Irf6 in keratinocyte proliferation and differentiation. In the absence… CONTINUE READING

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