Interferon Regulatory Factor-1 and -2 Expression in Human Melanoma Specimens

  title={Interferon Regulatory Factor-1 and -2 Expression in Human Melanoma Specimens},
  author={Jennifer K. Lowney and Leslie D. Boucher and Paul E. Swanson and Gerard M. Doherty},
  journal={Annals of Surgical Oncology},
Background: Interferon regulatory factor (IRF)-1 and IRF-2 are nuclear transcription factors that respond to interferon-γ. IRF-1 acts as the effector arm of the interferon-γresponse in tumor cells, whereas IRF-2 binds to the same DNA consensus sequence and opposes IRF-1 activity. This effect is intact in human and murine tumor models, including melanomas; previous work in our laboratory demonstrated the tumor-suppressing activity of IRF-1 expression in in vivo models and the opposing effect of… CONTINUE READING