Interferon-Inducible Cholesterol-25-Hydroxylase Inhibits Hepatitis C Virus Replication via Distinct Mechanisms

  title={Interferon-Inducible Cholesterol-25-Hydroxylase Inhibits Hepatitis C Virus Replication via Distinct Mechanisms},
  author={Yongzhi Chen and Shanshan Wang and Zhaohong Yi and Huabin Tian and Roghiyh Aliyari and Yanhua Li and Gang Chen and Ping Liu and Jin Zhong and Xinwen Chen and Peishuang Du and Lishan Su and F Xiao-Feng Qin and Hongyu Deng and Genhong Cheng},
  booktitle={Scientific reports},
Cholesterol 25-hydroxylase (CH25H) as an interferon-stimulated gene (ISG) has recently been shown to exert broad antiviral activity through the production of 25-hydroxycholesterol (25HC), which is believed to inhibit the virus-cell membrane fusion during viral entry. However, little is known about the function of CH25H on HCV infection and replication and whether antiviral function of CH25H is exclusively mediated by 25HC. In the present study, we have found that although 25HC produced by CH25H… CONTINUE READING
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