Interferon-Gamma Release Assay Performance of Pleural Fluid and Peripheral Blood in Pleural Tuberculosis

  title={Interferon-Gamma Release Assay Performance of Pleural Fluid and Peripheral Blood in Pleural Tuberculosis},
  author={F. Liu and M. Gao and Xia Zhang and Fengjiao Du and H. Jia and Xinting Yang and Zitong Wang and L. Zhang and L. Ma and X. Wu and L. Xie and Z. Zhang},
  journal={PLoS ONE},
  • F. Liu, M. Gao, +9 authors Z. Zhang
  • Published 2013
  • Medicine
  • PLoS ONE
  • Background The diagnosis of pleural tuberculosis (TB) remains to be difficult. Interferon-gamma release assay (IGRA) is a promising method for diagnosing TB in low TB burden countries. The release of interferon-gamma (IFN-γ) by T lymphocytes increases at a localized site of infection with Mycobacterium tuberculosis antigen. This study aimed to examine the clinical accuracy of T-SPOT.TB on pleural fluid and peripheral blood for the diagnosis of pleural TB in high TB burden country. Methods 168… CONTINUE READING
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