Interferon-Gamma Promotes Infection of Astrocytes by Trypanosoma cruzi

  title={Interferon-Gamma Promotes Infection of Astrocytes by Trypanosoma cruzi},
  author={Rafael Rodrigues Silva and Rafael Meyer Mariante and Andr{\'e}a Alice da Silva and Ana Luiza Barbosa dos Santos and Ester Roff{\^e} and Helton C Santiago and Ricardo Tostes Gazzinelli and Joseli Lannes-Vieira},
  booktitle={PloS one},
The inflammatory cytokine interferon-gamma (IFNγ) is crucial for immunity against intracellular pathogens such as the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease (CD). IFNγ is a pleiotropic cytokine which regulates activation of immune and non-immune cells; however, the effect of IFNγ in the central nervous system (CNS) and… CONTINUE READING