Interferon-λ in the context of viral infections: production, response and therapeutic implications.

@article{Hermant2014InterferonIT,
  title={Interferon-λ in the context of viral infections: production, response and therapeutic implications.},
  author={Pascale Hermant and Thomas Michiels},
  journal={Journal of innate immunity},
  year={2014},
  volume={6 5},
  pages={563-74}
}
Interferon (IFN)-λ forms the type III IFN family. Although they signal through distinct receptors, type I (IFN-α/β) and type III IFNs elicit remarkably similar responses in cells. However, in vivo, type III and type I IFN responses are not fully redundant as their respective contribution to the antiviral defense highly depends on virus species. IFN-λ is much more potent than IFN-α/β at controlling rotavirus infection. In contrast, clearance of several other viruses, such as influenza virus… CONTINUE READING
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