Interferon- ζ/Limitin: Novel Type I Interferon That Displays a Narrow Range of Biological Activity

@article{Oritani2004InterferonN,
  title={Interferon- $\zeta$/Limitin: Novel Type I Interferon That Displays a Narrow Range of Biological Activity},
  author={Kenji Oritani and Yoshiaki Tomiyama},
  journal={International Journal of Hematology},
  year={2004},
  volume={80},
  pages={325-331}
}
Interferon ζ (IFN-ζ)/limitin has been regarded as a novel type IIFN by the Nomenclature Committee of the International Society for Interferon and Cytokine Research. IFN-ζ/limitin, which has some sequence homology with IFN-α and IFN-ß, has a globular structure with 5 α helices and 4 loops and recognizes IFN-α/ß receptor. Although it displays antiviral, immunomodulatory, and antitumor effects, IFN-ζ/limitin has much less lymphomyelosuppressive activity than IFN-α. Unique interactions between IFN… Expand
IFN‐ζ limitin: a member of type I IFN with mild lympho‐myelosuppression
TLDR
Although IFN‐ζlimitin displays antiviral, immunomodulatory, and antitumor effects, it has much less lymphomyelosuppressive activities thanIFN‐α, and little ability of IFN'ζ limitin to activate the Tyk2‐dependent signaling pathway may explain its uniquely narrow range of biological activities. Expand
Interferons : between structure and function
Interferons are a family of proteins that are released by a variety of cells in response to infections caused by viruses. Currently, we distinguish three types of interferons. They are classifiedExpand
Differential effects of a novel IFN-ζ/limitin and IFN-α on signals for Daxx induction and Crk phosphorylation that couple with growth control of megakaryocytes
TLDR
The results extend the understanding about thrombocytopenia in patients with IFN-α treatment as well as the possibility for the clinical application of human homologue ofIFN-ζ/limitin or an engineered cytokine with useful features of the IFN/ limitin structure. Expand
Interferons as Immune Regulators: A Rivalry between HCV and Interferons
TLDR
The pharmacodynamics of IFNs are described with an aim to decipher the possible involvement of HCV proteins in subverting these responses, since they have a strong impact in determining the efficacy of an IFN in HCV infected host. Expand
Interferon‐λs: the modulators of antivirus, antitumor, and immune responses
TLDR
Recent findings about the biology of IFN‐λs and their pathophysiological roles in viral infection, cancer, and immune responses of the innate and adaptive arms are summarized. Expand
Cloning and characterization of porcine interferon-δ-related genes identified by genomic database screening.
TLDR
Among all the PoIFN-δ subtypes detected, PoIFn- δ8 has the strongest antiviral and immunomodulatory activities. Expand
Chloroplast-based Overexpression Of Pharmaceuticals To Develop Cost-effective Therapeutics
TLDR
It was experienced that mature leaves contained high levels interferon compared to young and senescence leaves, and transplastomic technology is the best choice, now days, to overexpress pharmaceuticals cost-effectively. Expand
Novel interferon delta genes in mammals: cloning of one gene from the sheep, two genes expressed by the horse conceptus and discovery of related sequences in several taxa by genomic database screening.
TLDR
Phylogenetic analysis indicates that the newly defined IFN-delta family includes murine Limitin/IFN-zeta, their closest neighbor, but is clearly distinct from all other type I families. Expand
Macrophages and cytokines in the early defence against herpes simplex virus
TLDR
Many positive feed-back mechanisms and synergistic interactions intensify these systems and give rise to heavy antiviral weapons such as reactive oxygen species and nitric oxide which results in the generation of an alliance against the viral enemy. Expand
Herpes Simplex Virus Evasion of Early Host Antiviral Responses
TLDR
A comprehensive understanding of how HSVs evade host early antiviral responses could contribute to the development of novel therapies and vaccines to counteract these viruses. Expand
...
1
2
...

References

SHOWING 1-10 OF 55 REFERENCES
Type I interferons and limitin: a comparison of structures, receptors, and functions.
The type I interferon (IFN) family includes IFN-alpha, IFN-beta, IFN-pi, and IFN-tau. These molecules are clustered according to sequence homologies, use of the same cell surface receptor, andExpand
Differences in Activity between α and β Type I Interferons Explored by Mutational Analysis*
TLDR
The structural basis for functional differences in α and β interferon subtypes is defined and a subset of these latter mutations did reduce activity in a manner analogous to IFN-α mutations. Expand
A new interferon, limitin, displays equivalent immunomodulatory and antitumor activities without myelosuppressive properties as compared with interferon-alpha.
TLDR
Strong immunomodulatory, antitumor, and antiviral effects with weak myelosuppressive and weak acute toxic effects of limitin indicate that it may be useful as a new therapeutic drug for virus-hepatitis and cancers. Expand
Anti-rhinoviral activity of recombinant and hybrid species of interferon alpha.
TLDR
IFN-alpha J1, and IFn-alpha C were the most active of the interferons, and were all more active than IFN- alpha A, against RV 39, RV 1A, and VSV, and warrant further study against rhinoviruses and other viruses. Expand
Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons.
TLDR
Recent developments in the understanding of the antiviral and immunoregulatory properties of IFN-alpha, the nature of the multisubunit IFn-alpha receptor, and the molecular mechanisms of signal transduction are reviewed. Expand
Characterization of N-Terminal Interferon τ Mutants: P26L Affords Enhanced Activity and Lack of Toxicity
TLDR
The structural basis for the activity of type I IFNs was examined, focusing on amino acids within helix A and the first section of the AB loop, which have been proposed as a site for receptor interaction, and the IFN- τ P26L mutant may have potential as an improvedIFN-based therapeutic. Expand
Interferon-κ, a Novel Type I Interferon Expressed in Human Keratinocytes*
TLDR
Interferon-κ therefore defines a novel subclass of type I interferon that is expressed in keratinocytes and expands the repertoire of known proteins mediating host defense. Expand
IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex
TLDR
The identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state and may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs. Expand
Ligand-induced association of the type I interferon receptor components
TLDR
Cross-linking shows that IFNAR and IFN-alpha/beta R are components of a common type I IFN receptor, cooperating in ligand binding, and probably triggers transmembrane signaling. Expand
A New IFN-Like Cytokine, Limitin Modulates the Immune Response Without Influencing Thymocyte Development1
TLDR
It can be speculated that the human homolog of limitin may be applicable for clinical usage because of its IFN-like activities with low adverse effects on, for example, T lymphopoiesis, erythropoiesi, and myelopoiedis. Expand
...
1
2
3
4
5
...