Interferon- ζ/Limitin: Novel Type I Interferon That Displays a Narrow Range of Biological Activity

  title={Interferon- $\zeta$/Limitin: Novel Type I Interferon That Displays a Narrow Range of Biological Activity},
  author={Kenji Oritani and Yoshiaki Tomiyama},
  journal={International Journal of Hematology},
Interferon ζ (IFN-ζ)/limitin has been regarded as a novel type IIFN by the Nomenclature Committee of the International Society for Interferon and Cytokine Research. IFN-ζ/limitin, which has some sequence homology with IFN-α and IFN-ß, has a globular structure with 5 α helices and 4 loops and recognizes IFN-α/ß receptor. Although it displays antiviral, immunomodulatory, and antitumor effects, IFN-ζ/limitin has much less lymphomyelosuppressive activity than IFN-α. Unique interactions between IFN… 

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