Interferon-ε protects the female reproductive tract from viral and bacterial infection.


The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-ε as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, IFN-ε was not induced by known PRR… (More)
DOI: 10.1126/science.1233321


4 Figures and Tables

Blog articles referencing this paper

Slides referencing similar topics